A taste of traditional Italian medicine

Medical Ethnobotanist Cassandra Quave collecting plant specimens in Italy.

By Carol Clark

“Ethnobotany is the science of survival,” Cassandra Quave told a group of Emory students when they visited her field research site in southern Italy recently.

Quave, a medical ethnobotantist with Emory’s Center for the Study of Human Health, is documenting the traditional ways that people use plants in the Vulture-Alto Bradano region of Basilicata province, a landscape of rolling hillsides dominated by the dormant volcano Monte Vulture. She is also collecting specimens of medicinal plants that she will take back to her Emory lab for her drug discovery research projects.

The students were in Italy this June as part of the “Italian and Medical Humanities” course, a collaboration of Emory’s Italian Studies Program, the School of Medicine, the Center for Ethics and the Center for the Study of Human Health.

Their itinerary included a day with Quave, who immersed the students in the local life of the village of Ginestra. She took them on a walk through the surrounding countryside, identifying the traditional medicinal uses of plants they encountered along the way. A fourth-generation shepherd told the students about pastoral life, and truffle hunters demonstrated how they use dogs to hunt these gourmet delicacies.

Cassandra Quave takes students off the beaten track, to learn about agrarian life.

“The students got to see first-hand how important traditional knowledge of environmental resources can be to a community,” Quave says. “It would be very difficult for these people to survive without it.”

During a visit to a vineyard, Quave made a point of having the students pick and eat ripe mulberries off a tree. “Today, especially in the U.S., people are very disconnected from their environment and food sources,” she says. “For many of the students, this was the first time that they had ever eaten anything that they had harvested themselves.”

Basilicata is home to the Arbereshe ethnic minority in Italy, the descendants of Albanians who fled the Ottoman invasion of Albania five centuries ago. “They have maintained their language, which is very different from modern-day Albanian, and adapted to a new environment, while still keeping some of their homeland traditions alive,” Quave says. “Unfortunately, many of these practices are in a state of rapid decline. The Arbereshe language is listed as an endangered language and as the language disappears, so does much of the culture.”

Quave currently has a $1.8 million grant from the National Institutes of Health to pursue her research into how an extract from the elm leaf blackberry, a tree common in forests across Europe, might help fight antibiotic-resistant staph. Click here to read more about her research.

Here are more photos of the students in Basilicata. 

Photos courtesy of Cassandra Quave.

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Freshman friendship fuels bio-tech business

Watch a TEDxAtlanta talk by Solazyme co-founder Harrison Dillon, above.

Diane Cardwell wrote a feature for the New York Times about Solazyme, a company founded by two Emory grads who are using algae to create clean fuel and other products. Here’s an excerpt from the article:

"Starting when they became friends in freshman year at Emory University in Atlanta, Jonathan S. Wolfson and Harrison F. Dillon would take off into the mountains of Wyoming and Colorado for weeks at time. They spent their days hiking in the wilderness and their nights drinking bourbon by the campfire, talking big about how one day they would build a company that would help preserve the environment they both loved.

"They graduated, and the backpacking trips grew shorter and further between. Mr. Dillon went on to earn a PhD in genetics and a law degree, and ended up working as a biotech patent lawyer in Silicon Valley. Mr. Wolfson received law and business degrees from New York University and eventually started a software business. But the two still got together every year. And they kept talking about the company that, they imagined as time went on, would use biotechnology to create renewable energy."

Read the whole article in The New York Times.

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'Omic astronauts' blast off into a new genetic era

By Carol Clark

Ready or not, the ability to rapidly and cheaply sequence the human genome is set to shape our species, both biologically and socially. Some people are early adopters of the technology, eager to jump into this brave new world.

Kristopher Hite, a bio-chemist and a post-doctoral fellow working in a biology lab at Emory, is among these “omic astronauts.” He is heading into unknown territory, full of potential risks and rewards, by having his genome sequenced and added to the public database of the Personal Genome Project (PGP).

Are we on the road to “Gattaca?” The 1997 film is set in a future where genetic databases are used to bio-engineer “ideal” children and sort out the less ideal members of society. In the above video of a Google + Hangout, Hite discusses some of the potential scenarios of the emerging genetic era with Paul Root Wolpe, a bioethicist and director of the Emory Center for Ethics.

Hite’s interest in the Harvard-based PGP is both scientific and personal. He wants to learn more about his own ancestry while also adding to our general knowledge of genetics.

He checked with his closest family members before joining the project, and they all gave him a green light. Even future family members, however, could be affected by his decision.

“If I have kids, maybe they’ll think I’m crazy for doing it and maybe they’ll resent me,” says the 30-year-old Hite, adding that he could not resist the opportunity of having his genome sequenced for free.

Here is how the PGP sums up its aims on its Web site: “We are recruiting volunteers who are willing to share their genome sequence and many types of personal information with the research community and the general public, so that together we will be better able to advance our understanding of genetic and environmental contributions to human traits.”

Hite has yet to decide whether he will allow the PGP to attach his name to his genetic data. It was among the concerns he discussed in his conversation with Wolpe.

The truth is, no one knows all of the future implications, Wolpe says. On the one hand, genetic data will likely boost opportunities for tailor-made medical treatments that will make today’s health care seem crude by comparison. But every new technology comes with a dark side.

“With your whole genome available to someone, and 20, 30 years from now with really more sophisticated DNA synthesizers, somebody could potentially clone you without your knowledge or consent,” Wolpe says. “As I tell my students, there is no science fiction anymore. There’s virtually nothing that I read about as a kid that I thought was whacky and way out that we’re not doing or trying to do. So I think that we’re opening up a whole new world of not only opportunity and potential but also legal problems and medical problems and certainly security problems.”

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Superman: Just another uptight guy in tights

Where would Clark Kent go to change into tights in the era of cell phones? Henry Cavill ponders many heavy, existential questions in "Man of Steel."

With today's release of the summer action flick "Man of Steel," Emory Looks at Hollywood focuses on the classic hero's journey of Clark Kent and Superman.

Sure, a lot of adolescents think that they're bullet proof and able to leap tall buildings in a single bound. But Clark Kent really possesses those special powers. Growing up with his "normal" parents, he embodies a super-sized version of adolescent angst, says Jared DeFife, an Emory assistant professor of psychiatry and behavioral sciences.

Clark Kent's unique strength and talents are also the things that distance him from other people. Like most kids, he just wants to fit in. That adolescent identity struggle "is something we can all relate to," DeFife says. Watch the video below for his complete analysis.
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A wild view of medicine

What do chimpanzees, honey bees, wood ants and woolly bear caterpillars have in common? They all practice medicine without a license.

"These animals use medicines that they find in the environment they live in to fight their parasitic diseases," says Emory biologist Jaap de Roode. In a recent TedxEmory talk (see above video), de Roode describes recent findings about "animal doctors" in nature and the potential for humans to learn from them.

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