Thursday, November 14, 2013

Atlanta Science Festival offers chance for interactive outreach

"Group Intelligence," which uses the science of molecular behavior to create a flash mob experience, is one of the many activities planned for the Atlanta Science Festival.

By Carol Clark

“We’re building momentum,” says Jordan Rose, who is heading up community outreach for the first Atlanta Science Festival, set for March 22 to 29. “We have a lot to celebrate in Atlanta and Georgia when it comes to science and innovation. It’s important for the public to be aware of all the activities and career opportunities here related to science, technology, engineering and math.”

Two information sessions about the festival are coming up on the Emory campus, for faculty, staff and students who want to get involved as an exhibitor or as a science ambassador. The first session will be held on Thursday, November 14 at 5 pm in Atwood, room 316. The second session is set for Friday, November 15 at 1 pm in the Whitehead Biomedical Research Building, room 600.

The idea for the Atlanta Science Festival was sparked at Emory, says Rose, one of the co-founders of the event and associate director of Emory’s Center for Science Education. Joining Emory as founding partners are Georgia Tech and the Metro Atlanta Chamber.

More than 57 partners will be putting on events at more than 30 locations during the eight-day festival, including lectures, films, performances, exhibits, trivia contests, demonstrations, workshops, guided walks and more. Events at Emory will include public talks, tours of labs and LEED-certified buildings, and a special Theater Emory performance.

The festival will conclude on March 29 with the Exploration Expo in Centennial Olympic Park. “It will be a big, family-friendly science carnival,” Rose says.

About 100 exhibits, activities, demonstrations and performances are expected for the Expo, and the organizers are accepting proposals for booths through December 13. “We’d really like to see a strong Emory presence,” Jordan says. “We’re hoping for lots of hands-on activities, geared toward kids of different ages, that directly connect to Emory research.”

He notes that Emory exhibitors can apply for special funding being offered through the Center for Science Education and the Howard Hughes Medical Institute to cover most of their costs for participating.

Science students and faculty are also being recruited to visit K-12 classrooms during the festival. “The idea is for scientists to talk to kids about their passion for their careers and some of the unsolved questions and problems of the future,” Rose says. “We want to inspire the next generation of students to address some of those problems.”

Financial sponsors of the festival include the founding partners, as well as Mercer University, Mercer Health Sciences Center, the Center for Chemical Evolution, Georgia Bio, the Atlanta Science Tavern, Captain Planet Foundation and Women in Technology.

The Atlanta Science Festival joins a trend for cities across the country holding similar events, including the World Science Festival in New York. “The Atlanta festival is unique in its real focus on local resources and expertise,” Rose says. “We will also have a strong emphasis on the links between science and the arts,” he adds.

Wednesday, November 13, 2013

Organic chemists now forming global bonds

"When I return to Japan, I'm going to be bringing back a lot of new ideas," says Atsushi Yamaguchi, at work in an Emory lab. Chemistry labs in the NSF Center for Selective C-H Functionalization are boosting their power by collaborating instead of competing. Photo by Carol Clark.

By Carol Clark

Atsushi Yamaguchi, a graduate student of chemistry from Nagoya University in Japan, is spending most of the fall semester as an exchange student, working in the Huw Davies lab at Emory.

“In Nagoya, you only see buildings,” he says. “In Atlanta, I can see lots of trees and squirrels.”

But the best part of the exchange experience, Yamaguchi adds, is the insider’s view he’s getting of top organic chemistry labs throughout the United States that are part of the National Science Foundation’s Center for Selective C-H Functionalization (CCHF).

“Before I came here, I only talked about chemistry with my other lab members, who have my same specialty,” Yamaguchi says.

Now, he’s learning new techniques of hands-on chemistry at Emory, while also joining in regular video conferences with chemists from the 14 top U.S. research universities involved in the CCHF. “When I return to Japan, I’m going to be bringing back a lot of new ideas,” Yamaguchi says.

The CCHF, headquartered at Emory, is pioneering a whole new way for organic chemists to teach and do research. A National Center for Chemical Innovation, the CCHF is funded through a $20 million NSF grant.

“We’ve gotten used to collaborating nationally through video-conferences,” says Huw Davies, the CCHF director and Emory professor of organic chemistry. “Now we’re going international.”

Video conference sessions link the Emory lab to other top organic chemistry labs around the country through the CCHF, which is now poised to connect labs globally.

Boosted this fall by an additional $635,000 from the NSF program Science Across Virtual Institutes (SAVI), the CCHF is expanding to include organic chemistry labs in Nagoya University, the Korea Advanced Institute of Science and Technology (KAIST) in South Korea, Cambridge University in England and the Max Planck Institute in Germany.

Each year, students and post-docs from Emory and other universities involved in the CCHF can spend several months doing chemistry abroad, while foreign students spend time at labs in the United States.

“The idea is to have cultural exchanges while also building collaborative research,” Davies explains. “It’s an incredibly valuable experience for students, who will ultimately be involved in research in a global environment as organic chemistry enters a new era.”

Traditionally, organic chemistry has focused on the division between reactive, or functional, molecular bonds and the inert, or non-functional bonds carbon-carbon (C-C) and carbon-hydrogen (C-H). The inert bonds provide a strong, stable scaffold for performing chemical synthesis on the reactive groups. C-H functionalization flips this model on its head.

Watch a video on how the CCHF is changing chemistry research and education:


“Governments around the world are investing hundreds of millions of dollars into C-H functionalization research,” Davies says. “In terms of organic synthesis and new methods of synthesis, it’s where the action is.”

C-H functionalization holds the potential to make organic synthesis faster, simpler and greener, and could open up whole new ways to develop drugs and other fine-chemical products, for use in everything from agriculture to electronics.

Many challenges remain, however, before C-H functionalization can be fully optimized for broad applications. The global network forged by the CCHF brings together leading players from around the world, representing a range of specialties that will be required to make the critical breakthroughs necessary to bring C-H functionalization into the mainstream of chemical synthesis.

The CCHF’s new model for research, breaking down individual lab walls to create a global collaboration of chemists taking different approaches to similar problems, has already resulted in dozens of research papers.

The journal Science recently published a CCHF finding that resulted from a collaboration between the Davies lab at Emory and the lab of John Berry at the University of Wisconsin-Madison.

The Davies lab has developed a powerful rhodium catalyst to drive chemical reactions for C-H functionalization, and a special class of highly reactive dirhodium carbene intermediates. The lab has been refining these carbenes for more than 25 years, to tame their reactivity so they can be used to perform selective, controllable reactions.

Watch a video of the reaction involved in the research paper, above.

Efforts by the Davies lab and others to isolate and study the intermediate steps of the dirhodium metal complex reactions have been hindered by their extreme efficiency and speed, since they react at about 300 times per second.

The Berry lab found a way to freeze and stabilize one step of the process long enough to get an actual glimpse into the workings of the mechanism. Ultraviolet-visible spectrometry showed the formation of a new molecule as the green starting material changed to a blue color that faded over time.

More collaborators helped give an even fuller picture of the intermediate compound. Jochen Autschbach from the University of Buffalo used density function theory to predict the nuclear magnetic resonance features of the compound, and Kyle Lancaster from Cornell University elucidated the compound’s structure using a series of X-ray absorption spectroscopy experiments.

“This is a seminal paper for the fundamental understanding of this chemistry, and it could not have been done without the ability to collaborate across a wide range of specialties,” Davies says. “Our lab has been broadly making C-H bonds functional for years, but there was always this mysterious black box that we couldn’t see into during the reactions. Now we can test the theoretical, computational models we’ve developed against the actual reactions. We can gather more information about bond strength and electron properties, so we’re not doing research in the dark.”

Davies expects the breakthrough to speed up the process of refining and improving the rhodium catalyst, one of the most promising and versatile of the multiple approaches under way to bring C-H functionalization to the forefront of organic chemistry.

Related:
NSF chemistry center opens new era in organic synthesis

Tuesday, November 12, 2013

The math of peer pressure


Peer pressure on decision-making begins when individuals directly connected to each other first reach agreement, then – under the influence of peers not directly connected to them – the entire social group eventually tips into a social consensus.

An analysis of this process conducted by Ernesto Estrada, a visiting scholar at Emory’s Institute for Quantitative Theory and Methods (QuanTM), was recently published in the Nature journal Scientific Reports.

“Consider a teenager who is pressed by her friends into binge-drinking on a Saturday night,” says Estrada, noting that this represents direct pressure from peers. “However, she is also under indirect pressure, by seeing that many teenagers are doing the same thing every Saturday.”

This indirect pressure can make the difference in whether an individual copies a given attitude.

Using mathematical models, Estrada analyzed data taken from 15 networks – including U.S. school superintendents and Brazilian farmers – to outline how peer pressure shapes consensus, leadership and innovations in social groups.

“Reaching consensus about vital topics – such as global warming, the cost of health care and insurance systems, and healthy habits – is crucial for the evolution of our society,” says Estrada, who is a mathematician based at the University of Strathclyde in Scotland.

Read more at the University of Strathclyde’s web site.

Related:
New institute taps the power of ‘big data’

Image: iStockphoto.com 

Tuesday, November 5, 2013

Grandiose narcissism reflects U.S. presidents' bright and dark sides

Narcissus was doomed to pine away his life, riveted by his own reflection.

By Carol Clark

Narcissus, the physically flawless character of Greek mythology who wound up falling in love with his own reflection, hardly seems like a good role model. For those dreaming of becoming president of the United States, however, some narcissistic traits may be worth fostering, suggests an analysis by Emory psychologists.

They found that grandiose narcissism in U.S. presidents is associated with ratings by historians of overall greatness of presidencies, as well as high marks for public persuasiveness, crisis management, risk-taking, winning the popular vote and initiating legislation. On the flip side, the study showed that grandiose narcissism is also associated with some negative outcomes, such as presidential impeachment resolutions, cheating and bending rules.

The journal Psychological Science is publishing the results of the analysis, led by Ashley Watts, a graduate student of psychology at Emory, and Scott Lilienfeld, Emory professor of psychology. Co-authors included Emory psychologist Irwin Waldman and graduate student Sarah Francis Smith, as well as University of Georgia psychologists Joshua Miller and Keith Campbell, both recognized experts on narcissism.

“Most people think of narcissism as predominantly maladaptive,” Watts says, “but our data support the theory that there are bright and dark sides to grandiose narcissism.”

Lyndon B. Johnson scored highest on markers of grandiose narcissism, followed by Theodore Roosevelt, Andrew Jackson, Franklin D. Roosevelt and John F. Kennedy.

Lyndon B. Johnson was known both for getting tough legislation passed, and for being "a bit of a bully," Lilienfeld says.

“It’s interesting to me that these are memorable presidents, ones that we tend to talk about and learn about in history classes,” Watts says. “Only rarely, however, do we talk about most of those who had low ratings for grandiose narcissism, like Zachary Taylor and Millard Fillmore.”

The researchers also found that presidents exhibit elevated levels of grandiose narcissism compared with the general population, and that presidents’ grandiose narcissism appears to be rising over time.

“As the importance of television and other media has grown in presidential elections, this could be giving an edge to those with the attention-seeking, outgoing personalities associated with grandiose narcissism,” Lilienfeld says.

In psychology terms, narcissism comprises at least two largely distinct patterns of behavior associated with different traits. Vulnerable narcissism is marked by excessive self-absorption, introversion and over-sensitivity. Grandiose narcissism, on the other hand, is characterized by an extroverted, self-aggrandizing, domineering and flamboyant interpersonal style.

“We don’t believe there is a specific dividing line between normal and clinical narcissism,” Lilienfeld says. “It’s probably inherently blurred in nature.”

A queen obsessed with being "the fairest of them all" illustrates a worst-case scenario of narcissism and leadership in the classic fairy tale "Snow White."

Their analyses drew upon personality assessments of 42 presidents, up to and including George W. Bush, compiled by co-authors Steven Rubenzer and Thomas Faschingbauer for their book “Personality, Character and Leadership in the White House.” More than 100 experts, including biographers, journalists and scholars who are established authorities on one or more U.S. presidents, evaluated their target presidents using standardized psychological measures of personality, intelligence and behavior.

For rankings on various aspects of job performance, the analysis relied primarily on data from two large surveys of presidential historians: One conducted by C-SPAN in 2009 and a second conducted by Siena College in 2010.

Lyndon Johnson’s mixed presidential legacy reflects both positive and negative outcomes tied to grandiose narcissism, Lilienfeld says. “Johnson was assertive, and good at managing crises and at getting legislation passed. He also had a reputation for being a bit of a bully and antagonistic.”

Franklin D. Roosevelt, he adds, was also a highly assertive, dominant personality, but not particularly antagonistic or impulsive.

“In U.S. history, there is an enormous variety in presidential leadership style and success,” Lilienfeld says. “One of the greatest mysteries in politics is what qualities make a great leader and which ones make a disastrous, failed leader. Grandiose narcissism may be one important part of the puzzle.”

The study of narcissism and the presidency follows an earlier analysis by Lilienfeld and colleagues that showed that the fearless dominance associated with psychopathy may be an important predictor of U.S. presidential performance.

Related:
Psychopathic boldness tied to U.S. presidential success

Credits: Top image shows detail from painting "Echo and Narcissus" by John William Waterhouse; LBJ photo from official White House photo collection; engraving of "Snow White" queen from the Project Gutenberg archives.

Monday, October 28, 2013

Tell-tale toes point to oldest-known fossilized bird tracks from Australia

The bird tracks were found on a slab of sandstone. Photo by Alan Tait.

By Carol Clark

Two fossilized footprints found at Dinosaur Cove in Victoria, Australia, were likely made by birds during the Early Cretaceous, making them the oldest known bird tracks in Australia.

The journal Palaeontology is publishing an analysis of the footprints led by Anthony Martin, a paleontologist at Emory University who specializes in trace fossils, which include tracks, burrows and nests. The study was co-authored by Patricia Vickers-Rich and Michael Hall of Monash University in Victoria and Thomas Rich of the Museum Victoria in Melbourne.

Much of the rocky coastal strata of Dinosaur Cove in southern Victoria were formed in river valleys in a polar climate during the Early Cretaceous. A great rift valley formed as the ancient supercontinent Gondwana broke up and Australia separated from Antarctica.

“These tracks are evidence that we had sizeable, flying birds living alongside other kinds of dinosaurs on these polar, river floodplains, about 105 million years ago,” Martin says.


An illustration showing how the landing track was probably made as a bird set down on the moist sand of a river bank. Drawing by Tony Martin.

The thin-toed tracks in fluvial sandstone were likely made by two individual birds that were about the size of a great egret or a small heron, Martin says. Rear-pointing toes helped distinguish the tracks as avian, as opposed to a third nearby fossil track that was discovered at the same time, made by a non-avian theropod.

A long drag mark on one of the two bird tracks particularly interested Martin.

“I immediately knew what it was – a flight landing track – because I’ve seen many similar tracks made by egrets and herons on the sandy beaches of Georgia,” Martin says.

The landing track fossil.
Martin often leads student field trips to Georgia’s coast and barrier islands, where he studies modern-day tracks and other life traces, to help him better identify fossil traces. (Check out Martin's blog, Life Traces of the Georgia Coast.)

The ancient landing track from Australia “has a beautiful skid mark from the back toe dragging in the sand, likely caused as the bird was flapping its wings and coming in for a soft landing,” Martin says. Fossils of landing tracks are rare, he adds, and could add to our understanding of the evolution of flight.

Today’s birds are actually modern-day dinosaurs, and share many characteristics with non-avian dinosaurs that went extinct, such as nesting and burrowing. (Martin previously discovered the trace fossils of non-avian dinosaur burrows, including at a site along the coast of Victoria.)

The theropod carnivore Tyrannosaurus rex had a vestigial rear toe, evidence that T. rex shared a common ancestor with birds. “In some dinosaur lineages, that rear toe got longer instead of shorter and made a great adaptation for perching up in trees,” Martin says. “Tracks and other trace fossils offer clues to how non-avian dinosaurs and birds evolved and started occupying different ecological niches.”

Modern-day landing tracks of a tri-colored heron, on the beach of Jeckyl Island off the coast of Georgia, show the similarity to the fossil tracks. Photo by Anthony Martin.

Dinosaur Cove has yielded a rich trove of non-avian dinosaur bones from dozens of species, but only one skeletal piece of a bird – a fossilized wishbone – has been found in the Cretaceous rocks of Victoria.

Martin spotted the first known dinosaur trackway of Victoria in 2010 and a few other tracks have been discovered since then. Volunteers working in Dinosaur Cove found these latest tracks on a slab of rock, and Martin later analyzed them.

The tracks were made on the moist sand of a river bank, perhaps following a polar winter, after spring and summer flood waters had subsided, Martin says. “The biggest question for me,” he adds, “is whether the birds that made these tracks lived at the site during the polar winter, or migrated there during the spring and summer.”

One of the best records of the dinosaur-bird connection has come from discoveries in Liaoning province of Northeastern China, including fossils of non-avian dinosaurs with feathers. Samples of amber have also been found in Liaoning, containing preserved feathers from both birds and non-avian dinosaurs going back to the Cretaceous.

“In contrast, the picture of early bird evolution in the Southern Hemisphere is mostly incomplete,” Martin says, “but with these tracks, it just got a little better.”

Read more about the discovery on Martin's blog.

Related:
Polar dinosaur tracks open to trail to past
Dinosaur burrows yield clues to climate change