Tuesday, October 29, 2024

Bacterial pathogen shows alarming resistance to common cleaners, chemists discover


A new study reveals widespread resistance of a major bacterial pathogen to the active ingredients in cleaning agents commonly used in hospitals and homes. 

The American Chemical Society Infectious Diseases published the research led by chemists at Emory University. It demonstrates the surprising level of resistance to cleaning agents of multidrug-resistant Pseudomonas aeruginosa, a pathogen of particular concern in hospital settings. 

The study also identifies biocides that are highly effective against P. aeruginosa, including a novel compound developed at Emory in collaboration with Villanova University. The researchers describe how these biocides work differently than most disinfectants currently in use. 

“We hope our findings can help guide hospitals to reconsider protocols for the sanitation of patient rooms and other facilities,” says William Wuest, Emory professor of chemistry and a senior author of the study. “We also hope that our findings of a new mechanism of action against these bacterial strains may help in the design of future disinfectant products.” 

First authors of the study are Christian Sanchez (who did the work as an Emory PhD student in chemistry and, following graduation, joined the faculty at Samford University) and German Vargas-Cuebas, an Emory PhD candidate in microbiology through Laney Graduate School. 

“Resistance of pathogens to cleaning agents is an area that’s often overlooked,” Vargas-Cuebas says, “but it’s an important area of study, especially with the rise in antibiotic-resistant pathogens worldwide.”


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Monday, October 21, 2024

Exploring the nature of fathers

"My academic life informed my personal life and vice versa as I wrote the book," Rilling says. "It was an interesting interplay." (Photo by Kay Hinton)

In a new book, James Rilling interweaves his personal experiences as a son, husband and dad with the latest scientific insights into fatherhood. The MIT Press published “Father Nature: The Science of Paternal Potential.” 

“It’s about how and why human males evolved the capacity to be involved caregivers, how that care benefits their children, and the circumstances in which it is more common,” says Rilling, a professor in Emory University’s Department of Psychology and Department of Psychiatry and Behavioral Sciences. “The intended audience is anyone who is, has or knows a father.” 

Rilling explores the neural basis of human social cognition and behavior as the director of the Laboratory for Darwinian Neuroscience. Around the time of the birth of his first child, he realized that paternal caregiving was a neglected research topic and he decided to make it a focus of his lab. 

He also began teaching an undergraduate course on fatherhood.


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Tuesday, October 15, 2024

Spiny Mice Point to New Path in Neuroscience

Spiny mice live in arid environments in Africa, the Middle East and southern Asia.

By Carol Clark

Scientists zeroed in on brain circuitry powering the desire of spiny mice to live in large groups, opening the door to a new model for the study of complex social behaviors in mammals. 

Current Biology published the work led by researchers at Emory University. It shows that neural signaling from the brain’s anterior cingulate cortex to the lateral septum drives the preference for spiny mice (Acomys) to affiliate with large peer groups. 

“To our knowledge, this is the first study to identify neural circuitry that promotes group-size preferences in a mammal,” says Aubrey Kelly, senior author of the study and associate professor of psychology at Emory. “We hope that our work paves the way for new insights into complex social behaviors in a range of mammals, including humans.” 

The Kelly lab made the breakthrough by developing methods to use spiny mice as a laboratory model for social neuroscience. 


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Wednesday, September 11, 2024

Large theropods thrived near South Pole, Australian tracks show

Melissa Lowery and Anthony Martin, co-authors of the new paper, examine a theropod track.

A discovery of dinosaur tracks on Australia’s southern coast — dating back to the Early Cretaceous when Australia was still connected to Antarctica — indicates that large theropod dinosaurs thrived in this polar environment, prowling the river floodplains when the ice thawed during the summers. 

The journal Alcheringa published the analyses of the tracks made in the Wonthaggi Formation south of Melbourne between 120 and 128 million years ago. The find includes 18 theropod tracks and four tracks made by ornithopods — small, herbivorous dinosaurs that may have been prey for the theropods. 

“These numerous tracks are the best evidence yet that these former polar environments supported large carnivores,” says Anthony Martin, first author of the study and a professor in Emory’s Department of Environmental Sciences. “The large theropods would likely have fed on prey such as smaller dinosaurs, fish and turtles.” 

Theropods, from the ancient Greek for “wild beast foot,” are a dinosaur clade characterized by walking on two legs and feet with three clawed toes. They belong to the same evolutionary group as Allosaurus, Tyrannosaurus rex and Velociraptor. 

The largest track from the current find was 18.5 inches long. “The hip height of that theropod would have been about the same as the full height of a tall, modern-day human — or a bit more than six feet tall,” Martin says.

Read the full story here.

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Tuesday, September 10, 2024

The promise and pitfalls of 'climatopias' for building resilience in coastal communities

"We need to invest in projects for low-income groups because they are the most impacted by climate change," says Jola Ajibade, associate professor in Emory's Department of Environmental Sciences. (Photo by Carol Clark)

By Carol Clark

Idowu (Jola) Ajibade grew up in Lagos, Nigeria, a low-lying city built around a lagoon bordered by the Atlantic Ocean. Flooding is a routine occurrence during the rainy season. 

“It was bad,” Ajibade recalls of living on the ground floor of a building during her early childhood. “We would get inundated with water until my family relocated to the upper level in a rental apartment. I don’t have many childhood photos or videos like most people. Our belongings got flooded out yearly — we replaced some items, but some things are just irreplaceable.” 

These experiences are part of what drove Ajibade, associate professor in Emory’s Department of Environmental Sciences, to become an environmental and human geographer. She explores how climate change is transforming the lives, livelihoods, social-cultural landscapes and housing access for low-income groups and historically marginalized communities. 

Nature recently published a commentary by Ajibade and Sameer Shah from the University of Washington considering whether futuristic settlements on water, so-called “climatopias,” are viable ways to build resilience in coastal communities. 

As urban populations boom, even as climate change exacerbates flood risks in coastal areas, governments are working with developers, architects and engineers to try to make their cities more resilient. Many leaders are promoting showcase climatopias as viable solutions. 

Ajibade and Shah, however, take a more cautious approach in their Nature commentary. “Ultimately, climatopias can become technical solutions to a complex global challenge only if stricter planning processes, impact assessments, ecosystem protection and justice for communities are at the heart of any coastal future,” the authors write. 

Examples of climatopias

The Maldives Floating City is a development of modular floating platforms taking shape in the Indian Ocean, set for completion in 2027. The development aims to help the Maldives, one of the world’s low-lying nations, survive the effects of rising sea levels. 

Maasbommel in the Netherlands offers an example of an amphibious climatopia. The 32 amphibious homes of Maasbommel are anchored to the ground but also fastened to flexible mooring posts that allow them to move upward by more than five meters and float during floods. 

Reclamation, or the practice of creating new land from oceans by filling the water with rock, cement and other materials, forms the basis for other climatopia projects worldwide. One famous example is Eko Atlantic, an enclave of sleek, modern skyscrapers rising on a two-square-mile platform of reclaimed land on the Lagos waterfront. 

Dredging for Eko Atlantic began in 2009, and construction is still underway. When completed, Eko Atlantic will comprise offices and luxury condos expected to house 250,000 residents, who will be protected from storm surges by an eight-mile-long, 20-foot-tall wall of concrete and granite. 

Developers laud Eko Atlantic as a way to attract transnational investment, drive economic growth, combat the effects of climate change and house more people in one of the world’s fastest-growing megacities. 

Getting multiple perspectives 

While working on her PhD as a graduate student at Western University in Canada in 2012, Ajibade returned to her hometown to research community vulnerability and resilience in Lagos, a city sharply divided between the rich and poor. 

“I talked to people who lived in slums and those in wealthy areas to get both their perspectives,” she says. “There was torrential rainfall during my visit and, at one point, I had to wade through chest-high water.” 

She notes that construction on the Eko Atlantic project has been blamed for displacing some communities and for diverting water in ways that increase the flooding burden on the poorest of the poor. Others counter that poor communities have caused the increase in flooding by building shanties on drainage systems and filling them with trash. 

Some believe that Eko Atlantic will benefit low-income people by providing service jobs. Others doubt that the economic boon of the pricy new real estate will “trickle down” in ways that benefit those who need it most. 

So is Eko Atlantic worth the billions of dollars that have already been invested in it during the past 16 years? 

“It depends on who you ask,” Ajibade says. 

Improving the drainage infrastructure throughout Lagos, including in the poorest areas, might be another solution that could benefit more people. 

“We need to invest in projects for low-income groups because they are the most impacted by climate change,” she notes. “Climatopias can’t be the focal solution, and they should be carefully considered so that they don’t damage fragile ecosystems, accelerate ocean colonialism or create even more problems for people who are already living on the margins of society.”

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