Chemists at Emory University invented a reaction to streamline the total synthesis of a compound, phaeocaulisin A, extracted from a plant used for centuries in traditional Chinese medicine.
In laboratory dish experiments conducted with biologists at Winship Cancer Institute of Emory University, the researchers showed the compound’s efficacy against HER2-positive breast cancer cells and triple-negative breast cancer cells. An analogue of the compound the chemists constructed boosted this efficacy.
“We not only efficiently replicated a complex natural product,” says Mingji Dai, Emory professor of chemistry. “We also improved upon it by turning it into a more potent compound.”
The Journal of the American Chemical Society published the work, led by Dai and Yong Wan, professor of pharmacology and chemical biology at Emory School of Medicine and director of basic research for the Glenn Family Breast Center at Winship Cancer Institute.
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