Wednesday, January 14, 2026

Epigenetics linked to high-altitude adaptation in Andes

Indigenous people living at high altitude in the Andean highlands have adapted to one of the most extreme environments ever inhabited by humans. (Getty Images/Oleh Slobodeniuk)

DNA sequencing technology makes it possible to explore the genome to learn how humans adapted to live in a wide range of environments. Research has shown, for instance, that Tibetans living at high altitude in the Himalayas have a unique variant of a gene that expands the oxygen-carrying capacity of their blood. 

Scientists, however, have not found a strong signal for this “high-altitude gene” in the genomes of Indigenous people living in the Andes Mountains of South America. It’s been less clear how people adapted to the altitudes greater than 2,500 meters in the Andean highlands, where low-oxygen levels, frigid temperatures and intense ultraviolet radiation make life challenging in the extreme. 

A study led by anthropologists at Emory University took a new approach to explore this Andean mystery.


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